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Research applications Tendon and ligament healing models, including Achilles tendon and transection studies Gastrointestinal research: gastric ulcer, NSAID-induced mucosal injury, and intestinal anastomosis models Angiogenesis and wound-healing assays examining VEGF-driven vessel growth Muscle injury and connective-tissue repair models Cytoprotection and organ-protection studies across multiple tissues In-vitro fibroblast migration and collagen-signalling work Study parameters reported in literature The published rodent work expressed doses on a body-weight basis rather than as fixed amounts — most often ~10 µg/kg, with a much lower ~10 ng/kg arm in several of the Sikirić experiments — and gut-focused models frequently used the oral route rather than injection

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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Mutinati M., Piccinno M., Roncetti M., Campanile D., Rizzo A., Sciorsci R.L