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Fidarestat administered in drinking water significantly reduced azoxymethane (AOM)-induced premalignant lesions in the colon of C57BL/KsJ-db/db obese mice accompanied by downregulation of PKC-β2, AKT, COX-2, and iNOS in the colonic mucosa, and decreased serum levels of IL-1α, IP-10, MIG, TNF-α and VEGF
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