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Russia and CIS Countries: Listed on the Russian List of Vital and Essential Drugs since December 7, 2011 Approved for ischemic stroke, transient ischemic attack, cognitive disorders, encephalopathy, and optic nerve atrophy Available as a prescription medication in two formulations (0.1% and 1% intranasal solutions) Also reportedly available in Ukraine, though formal regulatory documentation is limited United States: Not FDA-approved for any indication Has not undergone FDA clinical trials or new drug application review Cannot legally be marketed as a drug, food, or dietary supplement for human consumption Exists in a regulatory gray area as a research chemical when sold without therapeutic claims Not DEA-scheduled

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