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Multiple episodes of life-threatening acute cholangitis (infection within the bile ducts) can be seen due to impaired drainage of the bile ducts, which increases the risk of infection
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For example, the landmark phase III PACIFIC trial demonstrated improved overall and progression-free survival when consolidation anti-PD-1 therapy was added to conventional chemoradiation for patients with stage III, unresectable NSCLC, leading this approach to be adopted as a standard of care for this patient population [112]
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