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The authors stated that it is feasible to define PDC/DCA’s mechanism of action as inducing “fat necrosis” as findings included variably sized adipocytes engulfed by multinucleated giant cells, which is characteristic of the process of necrosis ( More recently, Bechara et al.’s group deduced that the mechanism of action of PDC/DCA was necrosis based on electron microscopy, which is considered the “gold standard” to differentiate apoptosis from necrosis

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For example, certain intestinal bacteria, such as Bifidobacterium , Clostridium , Enterococcus , Lactobacillus , and Pediococcus , can convert amino acids into polyamines through decarboxylation (111)