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Category 1 vs. Category 2. The FDA's peptide update, explained. Category 2 peptides are on the FDA's “difficult to compound” list, which effectively blocks licensed pharmacies from producing them. Category 1 means

In addition, they have been shown to improve nasal symptom severity and reduce NP size in patients with CRSwNP, leading to a significant increase in quality of life (Hayashi et al., 2016)

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Secondly, for the ARG form much of the information comes from patents and formulation descriptions, rather than from an extensive set of comparative publications