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This includes the upregulation of polyketide biosynthesis genes and ESX-1 secretion, which restricts phagosomal acidification and induces phagosomal rupture respectively [72]
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Patients received oral NAC in a dose of 1200 mg per day or placebo for one month, and the results show that administration of NAC increased levels of GSH as well as the ratio GSH : GSSG, while reduced levels of VCAM-1 and GSSG
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