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3.2 Post-translational modifications and protein stability of GPX4 The protein abundance and functional activity of GPX4 are not solely determined by transcriptional levels but are precisely regulated by a series of complex post-transcriptional and post-translational modification events, including but not limited to ubiquitination, interaction with specific proteins, and potential phosphorylation and glycosylation ( in vivo , demonstrating that p21 plays an important anti-ferroptotic role in OA progression by modulating GPX4 stability (Zheng et al., 2024)
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