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Oxidative TCA catalyzed by IDH1 and IDH2 is accompanied by the production of NADPH to balance the cellular redox equilibrium [28] and maintain the pool of reduced glutathione and peroxiredoxin that counteract reactive oxygen species (ROS) [29], protecting cells from oxidative damage, lipid peroxidation, and DNA damage [29,30]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Muscogiuri G, Gastaldelli A
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