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Research published in the Journal of the American College of Cardiology demonstrated that SS-31 preserved mitochondrial morphology and reduced ROS production by approximately 40% in cardiac ischemia-reperfusion models

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In embodiments, the c-Abl Kinase activator is (5-[3-(4-fluorophenyl)-l- phenyl-lH-pyrazol-4-yl]-2,4-imidazolidinedione or 5-(l,3-diaryl-lH-pyrazol-4- yl)hydantoin): (DPH) as described in Yang et al., “Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site, Chem

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