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The neuroinflammatory response in Parkinson's disease is mediated by the presence of activated microglial cells in the substantia nigra, with increased levels of proinflammatory cytokines in the striatum and the substantia nigra, and activation of the NF-κB pro-inflammatory pathway, which regulates target genes encoding proinflammatory cytokines, chemokines, growth factors and inducible enzymes [87]
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