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Ugi-4CR The Ugi four-component reaction (Ugi-4CR), featuring the condensation of a primary amine, an aldehyde, a carboxylic acid, and an isonitrile to produce an α-aminoacyl amide, has been widely applied in various fields of chemistry
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Compound 44 exhibited the highest docking score with a binding energy of −10.36 kcal/mol and formed five crucial hydrogen bonds with Gly225, Phe113, and the NADPH cofactor as well as stable binding throughout the simulation (RMSD ∼0.25–0.35 nm)
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