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For instance, ERK3 activity is required for KRAS-driven tumorigenesis in vitro, and ERK3 deficiency inhibits the oncogenic growth of KRAS (G12C)-mutant NSCLC in vivo, indicating the application of ERK3 inhibitors in KRAS (G12C)-driven tumours 180
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Furthermore, the composition of gut microbiota was also observed to be associated with complications and mortality in COVID-19 patients
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