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Figure 2 Crucially, chronic neuroinflammation is a factor in the development and progression of neurodegenerative diseases and subsequent neuronal damage
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The iron-responsive BMP/SMAD signaling pathway effectively upregulates hepcidin expression in hepatocytes, with the involvement of HJV further modulating signal transduction accessibility and specificity by forming a complex with the BMP receptor (BMPR) as a co-receptor, with HJV being tethered to the cell membrane via glycosylphosphatidylinositol (GPI) linkage (, )
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