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The committee developed and graded the recommendations and assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) framework.6 The committee members, who were selected jointly by the CVSA and a council member of the ANMS clinical guidelines committee, included primarily gastroenterologists with clinical and research expertise, providers from other disciplines, such as psychology and neurology, methodologists with experience in evidence appraisal and guideline development, and one patient representative, who was also President of the CVSA
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