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The proteomic changes induced by metabolic stresses include alterations in enzymes responsible for synthesizing peptidoglycan, arabinogalactan, and mycolic acids, leading to pronounced cell wall restructuring that further impedes antibiotic penetration (Trutneva et al., 2020)
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On the one hand, an overabundance of ROS activates multiple transcription factors, such as NF-κB and Nrf2, thereby inducing the synthesis of proteins that govern inflammation, cellular transformation, cell viability, proliferation, invasion, angiogenesis, and metastasis
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