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In any case, if the findings of this proof‐of‐principle study are confirmed, the use of probiotics during the gestational period may become an important adjuvant tool for pregnant women with PD (alone or associated with other systemic diseases, such as diabetes, metabolic syndrome, or obesity) and may even help to limit the extent of periodontal therapy during pregnancy while avoiding systemic adverse effects resulting from the disease

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4.2.2 Pulmonary fibrosis During pulmonary fibrosis progression, macrophage polarization promotes disease progression through signal pathway interaction and metabolic reprogramming