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Several investigations have shown that EDCs alter deiodinase activity, decrease thyroid hormone metabolism, restrict iodine absorption by thyroid cells, competitively inhibit thyroid transport protein TTR, and antagonize complexes arising from the thyroid hormone responsive elements (TREs) (Noyes et al., 2013)
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In spite of being one of the most widely distributed selenoproteins (probably due to its extensive lateral gene transfer, together with the corresponding selenocysteine synthesis and incorporation system) [29], FDH constitutes a key example where, as far as is presently known, selenium does not present any clear advantage over sulfur
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