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Both excitatory and inhibitory synapses are disrupted, with Aβ targeting key pre- and postsynaptic proteins, such as synaptophysin, synaptosome-associated protein 25 (SNAP-25), and postsynaptic density protein 95 (PSD-95) [11, 12]
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Given correctly this injection is rarely painful but the patient may get some rebound pain after 2 hours when the local anaesthetic wears off
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